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Apr 10, 2017 · Constipation with ulcerative colitis in Digestive Health

The microbial drug Mutaflor might be as effective as Asacol for the treatment of ulcerative colitis. Scaldaferri, F., Gerardi, V., Mangiola, F., Lopetuso, L.R., Pizzoferrato, M., Petito, V., Papa, A., Stojanovic, J., Poscia, A., Cammarota, G. and Gasbarrini, A., 2016. Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: an update. World Journal of Gastroenterology, 22(24), p.5505.

Mar 29, 2017 · Pemphigus Vulgaris in Autoimmune Diseases

“The interventions which appear promising, but will require further evaluation include adjuvant mycophenolate mofetil (MMF), azathioprine, intravenous immunoglobulins (IVIG), sulfasalazine and pentoxifylline, infliximab, epidermal growth factor and pimecrolimus.” Zhao, C. Y., & Murrell, D. F. (2015). Pemphigus vulgaris: an evidence-based treatment update. Drugs, 75(3), 271-284. A useful starting point for finding up-to-date information on medical therapies is to use “google scholar”.

Mar 17, 2017 · Possible Rare Condition or Just Chronic Pain? in Chronic Pain

(Absence of myoglobinuria does not necessarily rule out McArdle’s disease.) “About one half of all patients will have experienced myoglobinuria (dark urine) following intense exercise.”

“Oral sucrose (75 g) ingested 40 minutes before exercise improves exercise tolerance in McArdle disease.” “Effect of Oral Sucrose Shortly Before Exercise on Work Capacity in McArdle Disease” by S.T. Andersen, R.G. Haller, & J. Vissing, JAMA Neurology, June 2008

Aug 9, 2016 · Kleine-Levin syndrome/Lithium in Brain & Nervous System

Why should lithium therapy for KLS work in some cases and fail in other cases? The lack of a KLS animal model makes the preceding question extremely difficult to answer. How might KLS researches discover or develop animal models for KLS? Why am I personally interested in the preceding question?
Consider the following hypothetical table:
********************Prolonged high level****Prolonged low level
Acetylcholine:****catalepsy*****************Kleine-Levin episode Brown, D. W. “Abnormal fluctuations of acetylcholine and serotonin.” Medical hypotheses 40, no. 5 (1993): 309-310.

Do prolonged abnormal levels of serotonin and/or acetylcholine occur in PANDAS? Gerardi, D. M., Casadonte, J., Patel, P., & Murphy, T. K. (2015). PANDAS and Comorbid Kleine–Levin Syndrome. Journal of child and adolescent psychopharmacology, 25(1), 93-98.

Investigations of animal models of PANDAS might lead to insights concerning Tourette syndrome and, possibly, KLS.

Consider the following experiment: Over a 10-day period inject a group of mice with acetylcholinesterase and compare the injected group to a control group of non-injected mice. Repeat the experiment with an acetylcholinesterase-injected group of PANDAS-model mice and a control group of non-injected PANDAS-model mice.

“… A prospective cohort study was conducted with a sample of 77 non-consecutive patients observed between May 2009 and September 2010. … Results In the present study, 38 (49.6%) patients developed delirium during their intensive care unit stays. Neither serum acetylcholinesterase activity nor serotonin level was independently associated with delirium. No significant correlations of acetylcholinesterase activity or serotonin level with delirium/coma-free days were observed, but in the patients who developed delirium, there was a strong negative correlation between the acetylcholinesterase level and the number of delirium/coma-free days, indicating that higher acetylcholinesterase levels are associated with fewer days alive without delirium or coma. …”

Tomasi, C.D., Salluh, J., Soares, M., Vuolo, F., Zanatta, F., Constantino, L.D.S., Zugno, A.I., Ritter, C. and Dal-Pizzol, F., 2015. Baseline acetylcholinesterase activity and serotonin plasma levels are not associated with delirium in critically ill patients. Revista Brasileira de terapia intensiva, 27(2), pp.170-177.

Aug 8, 2016 · Kleine-Levin syndrome/Lithium in Brain & Nervous System Sveinsson, Olafur. “A striking response to lithium in Kleine–Levin syndrome.” Frontiers in neurology 5 (2014): 33.

Aug 7, 2016 · Facial Pain - Empty Nose Syndrome in Ear, Nose & Throat (ENT)

From Wikipedia, “In some people, surgery to restore missing or reduced turbinates may be beneficial. … About 21% of the people had no or marginal improvement but the rest reported significant relief of their symptoms. Since none of the studies used placebo or blinding there may be a strong placebo effect or bias in reporting.”

A patient suffering from Empty Nose Syndrome might consult the nearest ENT surgeon and get a recommendation for a specialist who performs turbinate reconstruction surgery — such specialists seem to be few in number so that there might be considerable difficulty in having the turbinate reconstruction performed.

Aug 7, 2016 · Autoimmune diagnosing problem in Autoimmune Diseases

@brie87144 @brie87144
As a non-physician, I shall give you my opinion, but keep in mind that my opinion might be completely worthless or DEVASTATINGLY DANGEROUS. My first impression upon reading about your symptoms is that you might have multiple sclerosis (MS), or perhaps some syndrome that is a differential diagnosis for MS, such as acute progressive multifocal leukoencephalitis or several other syndromes. “Multiple Sclerosis Differential Diagnoses”

From Wikipedia, “A person with MS can have almost any neurological symptom or sign, with autonomic, visual, motor, and sensory problems being the most common. The specific symptoms are determined by the locations of the lesions within the nervous system, and may include loss of sensitivity or changes in sensation such as tingling, pins and needles or numbness, muscle weakness, very pronounced reflexes, muscle spasms, or difficulty in moving; difficulties with coordination and balance (ataxia); problems with speech or swallowing, visual problems (nystagmus, optic neuritis or double vision), feeling tired, acute or chronic pain, and bladder and bowel difficulties, among others.”

If I thought I had MS, I might be crazy enough to try the following non-FDA-approved experimental therapy: