Chronic pain is complex. I have chronic pain in cervical spine, shoulders and arms. Doc says no surgical fixes. MRI shows several promblems in those regions. Recently cut way back in bydracodone due to constipation. Senna stopped being effective. Went to gastroenterologist and was told dependence on laxatives will cause no harm. What i use now TENS, topicals and the most effective is the large size tiger balm patches. If you have not tried them i suggest you do. Best price found on puritans pride web page. Ibalso take an herbal laxative which works.