I have spondylitis, a reactive arthritis in the spine and sacroiliac joints. It also causes colitis. Plaquenil (hydroxychloroquine) helped with the pain but caused a lot of itching in my arms and legs. I have found much relief through my diet and exercise. Pilates, walking and yoga help. A mainly Paleo diet keeps the inflammation down and the fatigue at bay. I recommend getting the book “The Wahls Protocol: A Radical New Way to Treat all Chronic Autoimmune Conditions using Paleo Principles.” It’s written by a medical doctor who suffers from multiple sclerosis. Basically you heal and nurture your body with food. The results can be life altering! She also has a TED talk. I hope this helps!