I have had many of the same symptoms as your wife. I am on my 2nd marriage with 2 children from the first marriage. My current husband did’t have any children of his own so we decided to have a baby. We lost the first preg. at 5 weeks. We became preg. again and during this preg. everything was somewhat normal, however at times I would be in horrible pain in my stomache, pelvic area and had a complete placenta previa. Luckily he entered the world a little early but appeared to be healthy. We assumed the first loss was a fluke until I became preg. again in 2007 resulting in a loss at around 8 weeks. Devistated, we hoped we would have the same exp. as last time and decided to try again. In Oct. of 2008 we became preg again, it was confirmed in Nov. and in Dec. I began to bleed. We paniced and went to see the Dr. I was put on strict bed rest which lightened the bleeding but it never stopped. It was later found that I again had a complete placenta previa and it was thought that the bleed was coming from a complication of the previa. I was in alot of abdominal pain and unable to gain weight, but refused to give up. My blood pressure was dropping horribly,sometimes as low as 80/40 and I was told if it continued I would have to start recieving transfusions or I could save myself through abortion, which I refused! Ultimatly God stepped in and on 2/17/09 our son was pronounced decieced! I had a D&C that day. We had our son autopsied because we were told most late term lossses are the bodies way of “getting rid of imperfection” or in other words he probably had a severe birth defect. The autopsy showed absolutly nothing wrong with our son. Due to the amount of pain during the preg. I was to follow up with gastro. I made the appt. which was months out, and began using birth control. As fate would have it I became preg. while on the Neuvaring and didn’t see gastro in time. This preg. had some lite bleeding in the 1st trimester but nothing like the other. Again I was in a ton of abdominal pain right behind my stomache/bladder. At around 25 weeks I went into labor and was hospitalized. They were able to hold off labor with large doses of magnesium which made me very sick. After 8 days of hospitalization and large doses of magnesium I was still having contractions but no cervical change. My husband and I decided if they coldn’t stop the contractions we could lie in wait at home. I was sent home on turbutaline 4 times daily and strict bed rest. At 28 weeks I had a positive fetal fibernecton and was told that ment I would probably have our son within the week. The contractions never stopped but somehow I managed to hold on to him until 35 weks. He was born small but seemingly healthy. In the midst of all this our other child began running fevers in excess of 105 degrees and the nodes in his neck would swell larger than golf balls. This seemed to be occuring in a pattern and we were refered to ENT. We had to wait for another flare up so they could do a CT. It revealed his large nodes but said they were reactive. After a few more flare ups it was decided to take the swollen nodes in hopes this was the problem. After his surgery he was still getting sick but not as regular and the fevers were not as high. We were than referred to an immunologist at Cardinal Glennon who discovered a deficiency of imuune system, the IgG’s. He was given a booster shot called a pneumovax shot and his system responded. After our last child was born I became increasingly sick. My hair was falling out, I was 138lbs when I delivered and within weeks I was downto 100lbs. my body is weak and I can’t get out of bed for any length of time without getting exausted. The abdominal pain is still there along with bowel issues. As time went on I began having joint pain esp. in my knees and shoulders. Not even a year after his birth I got Pnemonia. Did a course of antibiotics felt better for about 3 days and the Pnemonia returned. This time it was 2 months of antibiotics before I kicked it. During the course of antibiotics I developed a fungal (candida) infection due to the loss of good bacteria. I saw a gastro Dr. through Washington University in St. Louis mo who did an endoscopy on2/13/12. At the end of that same month I was drastically declining, down to 85lbs. My husband took me to several ER’s were we were treated like I was sick because of a “haabit.” Finally, on 2/28/12 he took me into one last ER this time St. Lukes hospital and I was seen by a Dr. who didn’t look at me as an addict and decided to run some “nt so normal” blood work but we would have to wait for the results and due to insurance reasons I was sent home. Two days later I had a police officer at my door telling us I was to return to the hos. immediatly, they had found something in my blood. As it turned out I had a bacterial blood infection Gram-Negative. After culture it was realized the bacteria in my blood is normally found in the digestive tract and since I recently had an enndo. w/biopsy it was believed to have entered my blood then! While I was hospitalized they actually listened when I told them about my sons immune problem and checked my IgG levels and you will probably find this hard to believe but I as well have a defeciency. While I was hos. my youngest child began with high fevers and large nodes in hi neck and has been sick once a month since. Everytime I take him to the Dr. it is thought he has strep but the test is always neg. So we begin testing on his immune system next month. I am steadily getting worse and my body is beat up! It is hard to get out of bed to enjoy the children we fought so hard to get here. I see immunology July 9th and I am going to Mayo in MN July 30th. Things that I have found that help are a glutin free diet, cut out added sugars (unnatural sugars) whey protein shakes, when made with frozen berries and yogurt they are tasty, probiotics, and I also recieve B-12 shots because my body no longer absorbs B-12 or vitamin D. Anemia can cause alot of her symptoms has she been checked? If not mabye trying a supplement, B-12 and/or Iron might help. I hope your family finds answers soon!