After 2 years on Pristiq the side effects became more than just a nuisance. My doc suggested switching to Cymbalta, after tapering off Pristiq. I started reducing my dose by 1/2 — 1 50mg tab every other day. After 2 weeks, the worse symptoms are nausea, increased pain (Pristiq really works for nerve pain) and a general feeling of ‘mental discomfort’ — being ‘on edge’.
Prior to Pristiq, I was on Lexapro; my doc switched to Pristiq because I complained of side effects. However, the side effects of Pristiq are definitely worse, and I think Lexapro did a better job controlling my depression.