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Feb 16, 2013 · Want to taper off Pristiq, makes my heart race in Depression & Anxiety

After 2 years on Pristiq the side effects became more than just a nuisance. My doc suggested switching to Cymbalta, after tapering off Pristiq. I started reducing my dose by 1/2 — 1 50mg tab every other day. After 2 weeks, the worse symptoms are nausea, increased pain (Pristiq really works for nerve pain) and a general feeling of ‘mental discomfort’ — being ‘on edge’.

Prior to Pristiq, I was on Lexapro; my doc switched to Pristiq because I complained of side effects. However, the side effects of Pristiq are definitely worse, and I think Lexapro did a better job controlling my depression.