Hi just read your post. Been living with Sjogren Syndrome and Lupus for over a year. These particular dieases are considered auto immune. Therefore your body is attacking itself. So you are going to have to make some major changes to compensate for the fatigue the pain and any other symptoms you may have. Good news though the plaquenil will resolve your fatigue. the only thing is it will take 3~6 months to kick in! Watch it the prednisone will help pain but it will make you gain alot of weight!!!!! Exercise when you can! DO NOT over do it!!!!! Your body will let you know.Take Care!!!!