I have stage 3 prostate cancer. I have been on Lipton for over a year. PSA went from 32 to .02 Starting chemo in august. Regional spread of the cancer to bones in the hip girdle and seminal vesicles. Surgery no help and complications you have read here outweighs any upside. Lupron has resulted in many negative side effects, including loss of sex drive almost completely, soreness and occasional muscle strains that come out of nowhere. Overall loss of energy of about 20-25%. Loss of muscle mass even though continue to work out. Weight gain initially of 10 pounds, now paying much more attention and have it under control. Hiking and exercise have been effective , much more difficult. NOW, having said all that, the fact that the cancer is pretty serious and those shots are controlling it, it pretty amazing. If you didn't really know me, you wold have no idea that I had cancer. I'm 63 so fairly young and in good condition. Good luck to you all.