I was diagnosed with RA in 2003 and was given Methotrexate- I took the medication once a week for about 9 years (off and on). I experienced nausea, no appetite, headache and light sensitivity for about 24- hours after taking the medication (also my mood was very sad- maybe from the side effects). My Rheumatologist had me tried different medications throughout the years but they did not helped with the pain, stiffness and fatigue. I was prescribed Xeljanz 10mg in 2014 (I was and still am scared about the long term side effects but it does help me and I only take 5mg daily- I have no side effects from it. I do still get flares, joint stiffness, pain, swelling- but much tolerable. On my last appointment he said he may increase it to 10mg if my flares were not under good control. The long term side effects from this medicine do scare me (that's why I only take 5mg). I have an appt in 2 week- I hope my inflammatory markers are ok. As far as Methotrexate I really don't think it helped with my RA symptoms and having the side effects every week was not a good thing.