Im recently diagnosed with acquired von Willebrand and Jak2, my platelets are around 600. I was put on 500mg Hydroxera then 3 weeks later 1000 mg of Hydroxera in APRIL 2019 and by May 5 I had flu like symptoms, fever 101.3, body ache etc. I stopped taking it for about 10 days was put back on and in 48 hours the symptoms were back. So Im one of those rare people who is allergic to Hydroxy. Interestingly my platelets fell to 163 with a 1,000mg dose. Is it possible that I was over medicated and that caused the reaction? It is clearly the best option as Allegraride may cause ventricular arrhythmia and Interferon makes people feel like they have the flu. My hematologist is not as concerned about bleeding as the blood clots that may result from the Jak2 mutation. My echo was great and Im otherwise healthy active and fit. Of interest to me in these discussions it is possible to have ET/Jak2 and not express disease. Is that true for Acquired Von Willebands/Jak2?