Hi Chuck216, I've received BR treatment twice [ 6 cycles each time] for CLL and have tolerated it fairly well. Pretreatment with Benedryl for the Bendamustine tended to knock me down and I was a little nauseated, but it passed a few days after each cycle. As others have said, the first infusion of Rituxan will be very slow. They start the drip rate slow to minimize reactions. I had rigors, and adding some benedryl helped. The nurses at the infusion center were the best. Advice? Treat yourself well – give your body time to recover after the second day – and stay hydrated. Best wishes.