Hi John. I also done the surgery. I waited 6 months to start Lupron as my PSA number was less than .1. My oncologist suggested I do radiation and Lupron as a precaution because my Gleason score on the prostate after removal and cultured was a 9. My PSA has not risen but I opted to do the treatments to be safe. I am a year and two months after surgery my PSA is less than .01. I can tell you there is side effects to Lupron, the two that bother me the most are upset stomach and a short temper. I am a very easy going person and the short temper even surprises me when it comes on in certain situations. On the radiation part of it was the hemorrhoids very painful, but now 3 months after radiation they are much better. The doctors say it can take up to a year to get back to normal from the radiation. I also discovered my blood sugar levels have went way up from the Lupron and might have to go on meds. Something I wasn't expecting, but hopefully now that the butt is feeling better I can get back to a more active life and get the blood sugar coming back down. Much luck to you on whatever you decide.