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Feb 20, 2019 · Other causes of failed PEth test for alcohol abuse? in Mental Health

Fair enough @fairlaneowner, I just wasn't sure if the red blood cells in the sample would react with the alcohol from the swab and create the PEth byproduct outside the body. Just a thought. I attached some information from the Substance Abuse and Mental Health Services Admin that has some interesting information on biomarkers including PEth test.

I still am waiting for my appointment with my provider who ordered the PEth test. The information in the SAMHSA brochure, which was directly referenced on my lab report, states that a single biomarker should not be damming and taken into context with other tests for a solid picture. This literature even says false positives are "unlikely but still unknown due to paucity of research".

Feb 20, 2019 · Other causes of failed PEth test for alcohol abuse? in Mental Health

I had a thought today that I wanted to share with this group. When I recently had an ethanol blood test the lab tech has to use iodine to clean the draw site so as to now contaminate the blood sample. When they drew blood for PEth, the tech used an alcohol swab and the site and it wasn't fully dry before the needle was inserted. Could this feasibly cause a false positive test. If they are worried about it with an ethanol sample it seems reasonable that it could affect a test that directly involves blood and ethanol. Also, the tube used for collection was the same tube used for a previous ethanol sample that hemolyzed. When I asked the tech about this, he said that for some reason they have issues with this particular "grey top" vial, but they used the same grey top for the PEth sample.

It might be a long shot and I'm not 100% on how it is formed other than interaction of red blood cells and ethanol, could that reaction occur in a blood vial?

Feb 14, 2019 · Other causes of failed PEth test for alcohol abuse? in Mental Health

Where did you read that? I've been searching. I'm trying to compile some data on the test results to show how inconclusive they are. Everything I've found contradicts what some other article states regarding PEth levels.

For example, one article I found says that 100–500 ng/mL is a "very low" positive and could result from Previous heavy drinking (1–3 days), previous light drinking (12–36 hours), recent “extraneous exposure”.

However, another article states that "A positive PEth result is a reading of over 20ng/mL or above. This is equivalent to excessive alcohol abuse. It is considered that a result of over 100ng/mL is very strong evidence to suggest heavy binge drinking." It also says that Research has indicated that a PEth test can differentiate between incidental exposure (such as hand sanitizer) and the intentional consumption of alcohol.

So which is it? And where did this mystical 20 ng/mL cutoff come from? and if that is the "positive" cutoff how can 100 ng/mL be "very low positive"? This test is bunk. I am too new to this forum to be able to post the article links….sorry.

Feb 13, 2019 · Other causes of failed PEth test for alcohol abuse? in Mental Health

On 4 January I had a full work up minus a PEth test and was normal, CDT was normal but GGT was slightly elevated, Doctor had no concerns, 29 January I had an Ethanol blood test that was negative. Now on 7 Feb I had an EtG test that was negative but the PEth that day was 653? I would have had to have been binge drinking everyday in January and then some to have a level that high and would have been positive on at least one ethanol test. 653?!? Shouldn't I be dead?

Feb 13, 2019 · Other causes of failed PEth test for alcohol abuse? in Mental Health

Good question, hope someone has an answer. I might try it out as the guinea pig and let you know. I have told my primary doctor that I have found non-alcoholic craft beer and he expressed little concern. Mouth wash and nyquil have more alcohol in them. Check out surreal brewing if you're interested in good non-a beer.

Feb 13, 2019 · Other causes of failed PEth test for alcohol abuse? in Mental Health

I joined specifically to comment in this group. I have regular and random alcohol use screening from two separate providers. I consistently pass GGT and CDT test but one provider decided to give me a PEth and Ethyl Glucuronide test. I passed the Ethyl Glucuronide test but had a 653 ng/mL PEth result well above the 20 ng/mL cutoff. Slightly worried and working on my rebuttal. Although this provider is not my primary care physician who actually handles and controls my case she can influence him. I just had an appointment with him and he has little concern about my abstinence. However, non-FDA approved testing can derail that apparently according to peoples posts.

I wanted to share this, it came directly from my lab results which I have full access to:
"Comments: Analyzed compound: PEth 16:0/18:1. 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol. Analysis performed by Liquid Chromatography with Tandem Mass Spectrometry (LC/MS/MS). Detection limit: 20 ng/mL PEth levels in excess of 20 ng/mL are considered evidence of moderate to heavy ethanol consumption. However, the Center for Substance Abuse Treatment (CSAT) advises caution in interpretation and use of biomarkers alone to assess alcohol use. Results should be interpreted in the context of all available clinical and behavioral information. Reference: Substance Abuse and Mental Health Services Administration (2012). \"The Role of Biomarkers in the Treatment of Alcohol Use Disorders\", 2012 Revision. Advisory, Volume 11, Issue 2. This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration."

I hope the comments will help someone else bolster their case as to the lack of validity using PEth as a sole biomarker.