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Thu, Feb 14 4:53pm · JAK2 Mutation - Effects and Questions in Blood Cancers & Disorders

Hello @kanaazpereira ,

The article you shared (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562533/ ) answers alot of my inquiry. Just wondering if there is any follow up article.

Abit of my background, I was diagnosed in Malaysia with CML in 1989 and underwent a Bone Marrow Transplant at the Hammersmith Hospital, London in 1990. I had a relapse in 1993 and has been well since. Recently, I had a drastic weight lost from 73kg to 60kg and did a bone marrow aspiration & Threpine (also tested for Philadephia Chromosome and it was negative) and Jak 2 test. I did Jak 2 test twice and it detected a faint band (on both occassion) which means, i am Jak 2 positive right?

My spleen is normal, doctor detected hepatomegaly during the ct scan.

According to my hematologist, the Bone marrow aspiration and threpine are normal which means, i am MPN negative. I am keen to know what happen to the 8 patients with Jak2 positive and No MPN after diagnosis (in the article).

@apr931 , i am Jak 2 positive with a normal bone marrow result. Have faith it may not or very slowly to progress.