I didn't have any issues other than the weight loss and belly pain. I was on antibiotics for roughly 29 days for a UTI that was misdiagnosed. I developed C-diff as a result of this and lost 20 pounds in less than 2 weeks. I was placed on vancomycin for approximately 60 days and that took care of the problem. I was also taking Bio-K plus probiotics for approximately 3 months and now take Florastor daily and have had no further issues. I hope this helps. I know how miserable C-diff is.