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Oct 13, 2018 · Blood Tests & Diagnosis in Autoimmune Diseases

Oh, and also, the reading I've done suggests that fibromyalgia is actually frequently a co-morbidity of other autoimmune disorders, including lupus. So, it's kind of ridiculous that being diagnosed with that would make any physician think you didn't also have an autoimmune disorder.

Oct 13, 2018 · Drug-Induced Lupus in Autoimmune Diseases

@nikohl7, meant to answer your other questions: yes, a chest x-ray was done, and my rheumatologist was extremely thorough in testing for everything under the sun. The only abnormal results for me were ANA, histone antibodies and chromatin antibodies. I'm very confused, too, about whether chromatin antibodies ever show up in people with drug-induced lupus.

Oct 13, 2018 · Blood Tests & Diagnosis in Autoimmune Diseases

Btw, medscape has many good articles on autoimmune disorders that go into diagnostic criteria, and that are free, if you haven't tried that yet.

Oct 13, 2018 · Blood Tests & Diagnosis in Autoimmune Diseases

Hi, @mcgke91. I feel your pain. I unfortunately have multiple medical problems, and have found some doctors to be dismissive if my symptoms don't fit into their box. Wrt your diagnosis, there actually are a few autoimmune disorders that can be seronegative, meaning that no blood tests come back abnormal. Psoriatic arthritis and reactive arthritis are good examples. I think that nikohl7 may've already said this, but lupus can show up as being seronegative in the beginning. I've now done pretty extensive reading on lupus through a service meant for physicians that goes into diagnostic criteria in detail (uptodate.com), and, from that reading, I also think your symptoms sound like lupus. Sounds to me like you need to consult with a different rheumatologist. Do you have that possibility? Don't give up hope. Your symptoms sound way more classic than mine, so I don't know why you couldn't find a doctor, including outside of a place like Mayo, who could give you a proper diagnosis and get you started on treatment.

Oct 13, 2018 · Drug-Induced Lupus in Autoimmune Diseases

Thank you, John, for your thoughts! I've gone to pubmed and uptodate.com for info, but Google Scholar is a good idea, too. The gabapentin was prescribed by my neurologist for my headaches. And it's not listed as being a potential trigger of drug-induced lupus. But, several medications in the anti-convulsant category ARE potentially triggers of drug-induced lupus. And, since my symptoms haven't subsided after being off zonisamide (an anti-convulsant prescribed to me for my migraines), I'm starting to wonder if something else I'm taking is triggering this.

Oct 13, 2018 · Drug-Induced Lupus in Autoimmune Diseases

Thanks so much for your supportive and encouraging note, Marilyssa! I'm really sorry to hear that you're in the middle of being diagnosed with possibly lupus. Waiting to get a more definitive diagnosis and treatment is difficult, to be sure. I agree with you that doing a lot of research is the best course of action. I've already done a lot of reading on uptodate.com, which is an excellent resource, that I highly recommend, if you haven't used it yet. (I checked with several physician friends who say that they use uptodate all the time.) They do charge, but as a lay person, you can get a week of access for a relatively low amount, and then you have a treasure trove of information designed for physicians.

Oct 11, 2018 · Drug-Induced Lupus in Autoimmune Diseases

Hello everybody, I developed an autoimmune disorder this summer, and my rheumatologist is in the process of trying to diagnose it. The possibilities in the mix right now are drug-induced lupus; lupus; psoriatic arthritis and reactive arthritis. I have a mildly positive ANA (1:160), a strong-positive for histone antibodies, and a positive for chromatin antibodies. My symptoms have mostly been myalgia and arthralgia, with some swelling of entire fingers and toes, mild serositis (chest pain), mild Reynaud's and before I was treated, extreme fatigue and malaise. There is no history of autoimmune disorders in my family, save for a cousin of my mom's who has rheumatoid arthritis. For what it's worth, I'm in my mid-40s and am white. I stopped taking the possible offending medication (zonisamide) about two months ago, and slightly prior to that, got started on methotrexate. My symptoms have significantly reduced since then, but I still have some pain and stiffness in my fingers from time to time, as well as on one side of my jaw. I've also been having nerve pain on the top of my head, but that may be unrelated. From the reading I've done, drug-induced lupus usually goes away within a few months, but sometimes can take up to half a year to go away. I'm guessing that given that I'm on methotrexate (15mg), my symptoms would reappear to some extent if I stopped taking it. This makes me wonder if I have one of the other possibilities, other than drug-induced lupus. However, I also feel a little worried that maybe we haven't correctly identified the medication that's triggering all of this. Unfortunately, I have severe, frequent migraines and allergies, so I'm on a slew of medications and supplements for that. In particular, I'm taking gabapentin, and wonder about that, given that it's in a category (anti-seizure medications) known to trigger reactions in people. I tend to have pronounced negative side effects to meds, so it wouldn't surprise me if this were drug-induced lupus, but who knows. Thanks SO much for any thoughts you have.