@pal131 I'm sorry to hear what you've been going through with bronchiectasis and MAC, and I relate to your story, having dealt with the same conditions for several years. Like you I was reluctant to try the "Big 3" but eventually the deterioration of my lungs and the frightening appearance of cavities in the lungs convinced me that I should try a regimen that might slow down or stop this obvious progression. What I've learned from my own experience on the drugs and from the Mayo Clinic forum is that the experience is different for everyone: the drugs have different side effects for different people, the treatment for the side effects is unique to each patient, and the effectiveness of the drugs is different for each patient. To top it all off the odds of actually eliminating the MAC infection are not encouraging. However, after you consult with a good, well-informed, wise pulmonologist and ID doctor, you may decide it's worth a try for you. Keep in mind that if you do decide to try it, and it's too hard on you, or it doesn't improve anything for you, you can decide to stop, and explore other options, though, admittedly, there are few. This experience is all about trial and error. I encourage you to have an open mind and consult with the best doctors you can find. In my case, after being on the drugs for 16 months, there is no improvement in my lung tissue, but I have more energy (on the days when I don't take the drugs), I cough hardly at all, and I contracted not one virus for 13 months. (I was getting a cold or flu or having a flare-up about once every 3 months before the drugs.) The drugs have not been fun for me but I've learned ways to tolerate them. Wishing you the best.