@taya Hi Taya, I've made 4 European river cruises with bronchiectasis over the last 12 years. The great thing about river cruises is their ability to accommodate people with a variety of capabilities. If you need to join the "gentle" walking group, you can do that. If you need to hear the lecture but tour on your own, you can do that. You won't get lost. You'll want to use your nebulizer in your state room, and no one will be bothered. I'm sure you won't want to bother other passengers with your cough, but the most important thing is to let them know your cough is not contagious — that's what they'll be worried about. If you have a bad coughing bout, you should probably move to your room until it settles down. As long as this is something you want to do, I can assure you it can be done, and you will have a great experience and learn a ton. Asking your doctor for advice well before you leave is a great suggestion, and of course make sure you travel not only with the medicine you do need, but also with medicine you might need. Bon voyage!