Your stepmother is not alone experiencing mental and emotional shifts on these drugs. Mental fog,anxiety getting upset and very sad were a way of life for me the first 6 months…..I hated the way I felt and knew it was the drugs but that was little solace. Eventually my body got used to these chemicals and I regained my composure, peace, and normal personality…I don’t think you can overestimate the havoc these drugs have on us….they are administered to attack the MAC but a side affect is damage to the parts of our brains which control our wellbeing. Arikayce is a new drug which may help as it does not enter the blood stream but goes straight to the lungs….you might look into to that for your step mother. Good luck. She is very lucky to have such a concerned stepdaughter.