I haven't posted in a while. I stopped tapering Effexor about a month ago when I started taking Methotrexate for rheumatoid arthritis. Didn't want to confuse my body! The new medication has been difficult as it causes nausea daily. So I am staying with my 75mg tab plus 37.5 tab of Effexor. Still an improvement over the 225 mg I started out with. Anyone who has had experience with methotrexate? Original dose of 6 tabs once a week was cut to 3 tabs due to the nausea. I can handle this better, but still unpleasant. Food is important!