Anyone experience having a enlarged spleen on and off after have mono or EBV? i had mono about 13 years ago. Mine is currently enlarged , but i have no other symptoms. Typically i have this feeling when stressed, sick or i drink. I know the feeling as when i had Mono it was extreme and my spleen was significantly enlarged and throbbed. This has been going on for the past 13 years and finally i went into the doctor during one if its episodes. They can feel my spleen. I am getting blood work and will have imaging done this week. The doctor doesn't think it is cancer as it has been going on to long without any other symptoms. i have had my full blown blood panel done several times over the past few years and everything has been normal. I am nervous but feel this may be the EBV in me that keeps striking when i am worn down and week. any thoughts?