I have completely tapered off Effexor ER, the last 37.5 in 1/4 increments over the course of a couple weeks. It was not difficult for me (thank God). I'm still recovering, however, including dealing with 40+ pounds I had gained! The big challenge will be the actual depression that precipitated me taking Effexor to begin with. I usually feel pretty good, although I'm a bit off today after biking 20+ miles yesterday. I might have over did it, maybe, perhaps. I do like to bite off more than I can chew, for sure. A bit of an excitement addiction. I guess. I need to be very careful to keep things simple, choose my friends wisely, set up boundaries, meditate so I'm not ruminating or obsessing.