I have been on Effexor XR/Venlafaxine XR for 20 years. I’ve been on 75 mg per day for the entire time, except for the past 5 months, when my dose was increased to 150 mg. When I was on the 75 mg dose, I tried many times to taper off of the drug. Like practically everyone else on this thread, I wasn’t successful due to the bad withdrawal symptoms. I’m going to be dropping back down from 150 mg to 75 mg in the next few weeks. At some point I would really like to be off this medication completely, but I have to say that I’m not very optimistic about being able to do it. It has been very helpful to read everyone’s comments. It makes me feel like I’m not alone.