This information is hard to ignore and the similarities are striking. Googling Omeprazole and facial swelling was a mind blower for me also! That never came up when I would google only facial swelling…. How fortunate that you had the sense to go to Mayo and have this testing! Having this testing done is imperative for me because the Rheumy I have been seeing has spoken to the fact that I have some kind of “gene mutation” that has caused this to happen. He also has referred to it as an immune deficiency, so I’m still a bit confused. I just did the calculations and I have actually been on a PPI for 15 years. I noticed back before this started that my face was starting to look bigger but it did not really resonate until 2015 when my glands where swollen too. I got a call from Mayo today and they want me to see an allergist/immunologist. When I called to make an appointment I believe they determined who I would see based on the ailment, mine being facial swelling. I’m wondering if that is the correct direction to go in or should I start somewhere else? I want to make the most of this visit because as many people do, I will be traveling there from another state. Regardless, I am going to stop taking the Omeprazole today. How long did it take for the swelling to subside after you stopped taking the PPI? Thanks so much again for providing me with this information if I am on the right track that gives me hope, if not it has given me encouragement that there are others that have dealt with tough heath issues and are persevering.