I have been taking Colestipol for a couple of years. I have diarrhea only IBS, so finding myself a little constipated is a bit of a relief. I take 1 at night along an Imodium in the morning and probiotics weekly. I find this regimen works for me most of the time, so that I am no longer nervous about leaving the house. There’s also a drug, hyoscyamine, that stops your gut in its tracks. I save that one for emergencies when I’m traveling.