I struggled with intermittent nausea for quite some time with Trintellix (15 mg). I would recommend “playing around” with the dosing (i.e. dosing 1/2 in the morning, 1/2 at night) with your doctor’s approval to try to find an acceptable dosage regimen without the nausea interplay. This medication (Trintellix) has REALLY worked wonders for me, so I am thankful for taking the time to “work through” this side effect. It does also seem to get better/less frequent with time.