I am in my second year of taking OFEV. I have shortness of breath with minimal exertion but I'm still able to work out in the yard, at a slower pace than a few years ago, I'm at the 80 mark so how much of that is age related? I recently had a colonoscopy, it was 5 years since the last exam. I have some cancer history in my family so wanted to double check as I was having difficulty getting the side affect of diarrhea under control. The colonoscopy revealed colon inflammation and the doctor prescribed Mesalamine for the inflammation and this did the trick. List price is about $1,000 for 90 day supply and with insurance is about $100. A possible substitute is Sulfasalazire @ $48 list. Hope this helps you with your situation, we're all different and we just need to keep pushing on.