@sueinmn I was on the Big 3 for 17 months and had the same thing happen. A new spot. I had a biopsy to confirm the spot was MAC It was a Granuloma but did culture MAC. Then they sent a susceptibility test to make sure it was still sensitive to Azithromycin.. Have they sent any susceptibility tests for you? I am still on the same regimen and going to get an opinion at Mayo in Rochester.