@tinaesims I started out the same. Positive cultures and really no other symptoms. They watched it for 2 years then when there were changes happening on my CT, they started the meds. I wished that they would have started them sooner before the changes showed on my CT. Now I am having a harder time getting rid of this. I was reading about NAC and L Glutathione. I am not sure if that will interact with the Big 3. I am now taking them daily. I do take Probiotics at least 3-4 hours after my dose. I do take Vitamin D. My ID MD told me if you want to help your immune system that is about the only Vitamin he would suggest.