I’ve been on three meds for 4 months now and have discovered what helps with the nausea is spacing the drugs out with an hour in between. For the weakness and fatigue, I don’t push myself when it hits, nap when I can, and take advantage of the times I feel good to get things done. For me, the side effects have waned somewhat over time, and it’s tolerable. My main concern, since I take ethambutol, is ocular toxicity. It’s really important to get tested regularly. If you have any visual changes, you should see an eye specialist within 2 weeks.