I have been on the Big 3 for 3 years (1.5 years 3x/wk and now 1.5 years daily) and recently (the past 3 months) have tinnitis in one ear. I am one of the lucky patients who have had no adverse drug reactions until now. I'm hoping to be able to end treatment in June, if my CT is favorable. Is there any hope that the tinnitis will end when I stop taking the Clarithromycin? If so, how long will it take?