with RA and the biologic modifers your whole immune system is suppressed. this means you can be subject to any viruses/ colds very easily. my experience with biologic modifiers was horrible, the worst being kidney failure which put me in the hospital until the kidneys came bac; torn retinas in both eyes requiring surgery; a severe rash in the groin which almost would have required losing my testicles. but that is my system. not everyone will experience what i had. also if you go on any biologic modifier have your liver enzymes check before and during the use of this medicine since a lot of it has to metabolize thru the liver…..i had at one time cellulitus and had c.diff. but the c.diff was after the removal of my gallbladder. c. diff can be eradicated with vancomycin orally, but it is a very strong antibiotic and can be hard on the digestive system, as i experienced. i was on it for 2 weeks and my stomach was hurting all the time.