We stayed at the Kahler Inn and Suites that had a mini kitchenette area. I didn't book a full-size kitchen option because I didn't know we would be there for a month (over Christmas and New Year's.). The Kahler Inn and Suites is also attached to Mayo and The Methodist Hospital. I can't say enough great things about the service! Anything I needed they were there to help. A huge free breakfast was provided each morning and there were plenty of restaurant/fast food/deli/pizza/cafeteria choices within walking distance via the underground tunnels. I ordered needed groceries online from Hyvee and had them delivered to the room. All grocery stores probably offer the delivery service now.:) I loved that there were no shuttles needed once we checked in. Anything I needed could be purchased close by or delivered.
If you are walking outside, you will appreciate having real water-proof insulated snow boots with good traction. (I found that parking lots tended to collect black ice.) I waited until we got there and went to one of the farm supply stores (Fleet Farm on 63 South) and bought the real deal at much lower cost than department stores here offering them for looks rather than usefulness. I am from warm South Carolina and items needed there aren't even sold down here. If you have any questions, please ask. Mayo Rochester is AMAZING!