@marellen From my understanding, the antibiotics are to treat the NTM, (MAC, MAI, etc.). The saline thru the nebulizer is to assist with lung clearance and in making the lungs less hospitable to various mycobacterium infections. Very important for those of us with bronchiectasis. I think most, if not all, on this forum do some type of lung clearance daily. Hope that helps a bit. Others on here are much more knowledgeable regarding this than I am.