@maryathome, I know /understand the feelings you are describing all too well. For me, part of the trick is figuring out if this is depression or what? And i dont really know the total answer. I was on the same drug combo of effexor and wellbutrin for about ten years. The last six months i had been put on Pristiq, a longer metabolizing version of effexor. But it suddenly stopped working and I was in a terrible state. Back then, I was originally diagnosed with premenstrual dysphoric disorder, and after menopause, major depressive disorder. I was on cymbalta, then vibryd, and then cymbalta again. So after 5 years of that, I had a full blown manic episode in 2015, at the age of 61! In retrospect, my Dr. thought I was actually likely to have really been bipolar type 2, and some changes in meds possibly would have prevented the mania. Tho it could have also been triggered in part due to steroid injections for my RA. I know this is all about me, but I am just trying to share that some of us face a lifetime of chronic mental health challenges and others have a more acute situation. So thats where the rubber meets the road: is it chronic? Is it the meds need adjustment or something else? 3 years later, I am still struggling to understand my own lack of motivation. Between that, RA, and aging issues, it's so complicated. Like you, Mary, i can also force myself going to/participating in a few activities but left alone, I have a terrible time getting myself to do Anything. Not cleaning or reading or crocheting or cooking or laundry. The t.v. is my constant companion! Not good. I wish you all the best on your journey!