That is a good question. All of us have different symptoms with minor similarities. What made us figure it out, though, is that many of the stressors that trigger our symptoms are the same. Also, the treatments for the stress response systems are helping both my son and daughter, even though they have different symptoms. The only thing we know genetically right now is that our son (17) has a gene mutation causing his cells to have a methylation dysfunction. In my mind and with my knowledge, this is plenty of a reason for his body to go into a state of emergency (dysautonomia) over the years. Nothing is able to get through the cell walls, toxins are stuck inside his cells, mitochondria are distressed, and his nutrients (including sugar) are just floating around in his body. (His urine had hundreds of tiny particles floating around in it — likely the undigested food.) He also cannot eat anything at all that calls for an insulin response (sugar, fruit, some vegetables, some nuts, any grains, even Vitamin B, etc.). Anytime insulin is called for, he has a massive, massive reaction that lasts for weeks (depending on how much glucose was present). I am the same way with sugar, but my reactions are much more acute. Complicating my son’s illness is the fact that he also has a vestibular dysfunction (aggravation the autonomic nervous system) AND unbelievably, has neuro autoimmunity, attacking the same area of the brain (frontal lobe). His strep levels in his body are so high that his doctor has diagnosed him more specifically with PANDAS. This is a very complex case and thankfully, we have found most of the pieces to the puzzle (though we are not sure how they all fit together yet). Thank you for letting me join in on the discussion. You have no idea what a relief it is to talk with other people who understand.