Webinar: What Women Need to Know about Ovarian Cancer

Tue, May 12
12:00pm to 1:00pm ET

Description

Mayo Clinic gynecologic cancer specialists Jamie N. Bakkum-Gamez, M.D. and John Weroha, M.D., Ph.D. discuss the signs and symptoms women should be aware of for detection of ovarian cancer, understanding treatment options, and the importance of new clinical trials. Mayo Clinic medical geneticist Myra J. Wick, M.D., Ph.D. discusses the importance of family history and genetic counseling in preventing ovarian cancer. A live question and answer session followed the presentation. You can still ask questions using the chat box to the right. Speakers include: - Jamie N. Bakkum-Gamez, M.D. - John Weroha, M.D., Ph.D. - Myra J. Wick, M.D., Ph.D. Would you like to: Request An Appointment Learn More About Ovarian Cancer

Location

Online
@beachtennis

If you are negative BRCA1/2, should we ask to have Lynch testing?

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Recommend discussing personal and family history with genetics professional to assess risk for Lynch syndrome

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@peggycampbell327

I am a stage 2c survivor; negative on both braca1 + 2 test. Am I correctly understanding that my sister remains at a 1.4% risk range? Or is her risk higher?

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There are other genes, aside from BRCA1 and BRCA2, that may have been associated with your ovarian cancer. Would recommend revisiting with a genetic counselor to discuss whether additional genetic testing is warranted. If you have one of the less common genes that has been implicated in ovarian cancer, your sister’s risk could be elevated above the general population risk.

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@lynnkw

Mother passed from ovarian cancer at 51 y.o. She was BRCA1 positive. Both my sister and I are negative for this gene mutation. Is there any reason for us to do any type of regular screening/preventative measures? are there any environmental or other factors that could ‘turn on’ this gene?

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You should not have to do any type of screening or preventative measures if you do not have the mutation identified for your mother.

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@sepdvm

Recent Foundation One testing of a metastatic squamous cell carcinoma of the lung lobe showed BRCA1 and BRCA2 as VUS (varients of unknown significance), present but unknown as to their effects on the SCC. Is this evidence that I carry both gene alterations and should consider preventative treatment for Ovarian cancer?

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Many types of tumors develop mutations in genes over time. Most often these mutations or alterations in tumors are not inherited. Encourage you to discuss results with your oncologist.

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@danmhaye

My sister had surgery at Mayo last week. It was too large and involved to remove and the oncologist is recommending traditional chemo which she is scheduled for at Mayo. Is she a candidate for the ovatar trial?

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Alex, thank you very much for the reply.

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@above

Please share your latest research on best preventing ovarian cancer from recurring (non hereditary, stage 3B after major hysterectomy))

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Dear Alex
Thank you for your reply. Are the clinical trials open to non-americans? Im Danish and might be willing to travel:-)
Best rgs
A

Sendt fra min iPhone
derfor lidt kort 🙂
bedste hilsner Anne

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I have been experiencing severe pelvic/abdominal pain. My u/s and ct showed I have a small mass on my left ovary and one on my uterus (a small cyst in my liver) and my alpha feta protein test was abnormal, CA125 was normal. My doctor says there is nothing to worry about, I see my gyny on the 2nd June. My question is: can a doctor tell by my test results that the mass is benign? I am a 58 yr old female. I took HRT for 7 years stopped 1 year ago. The pain is increasing in severity now extending into my back and the groin area, I have had to stop work and am taking painkillers Tramadol 24/7. Thank you for you help.

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@dugan

I have stage 4 recurring ovarian cancer. I have been treated with Chemo four 4 1/2 years after surgery. Was given 2/3 months and started treatment of HEXALEN. Is there any other treatment that you would suggest.

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There are many potential therapies for recurrent ovarian cancer and the pros/cons should be discussed with your local oncologist. It is difficult to give advice about what treatments to do now or next without having more information about your medical history, tolerability of prior chemo, life goals, physical condition, etc. The best way to answer this question is through a face-to-face consult or electronic consult if your physician is part of the Mayo Clinic Network.

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@mfell

I have stage 3 recurrent clear cell ovarian cancer. You mentioned carboplatin and taxol are the standard chemo treatments for ovarian cancer. Would you say they would be the same for clear cell? Thank you.

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Yes, we currently do not distinguish between the different subtypes of ovarian cancer and use the same general platinum-taxane doublet therapy (for instance cisplatin or carboplatin plus paclitaxel or Taxotere) for all subtypes.

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@above

Please share your latest research on best preventing ovarian cancer from recurring (non hereditary, stage 3B after major hysterectomy))

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Yes, international patients are eligible to participate. However, I would suggest you consider staying in the US rather than trying to travel back and forth. In addition, you should have complete records submitted with your “new patient registration” with a specific question to the Medical Oncology team to review candidacy for clinical trials prior to making an appointment. This could save you the potential problem of being disqualified based on prior treatments or other criteria.

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@cynthiawick

Dr. Weroha: participating in clinical trials DOES cost patients $$. Insurance doesn’t pay for the trial drug, true, but it may have to pay for the administration of it – even if it’s not SOC. And so patients end up paying the copay for the admin. of the drug. I paid over $110 every 3 weeks for the admin. of Avastin for a trial, plus $30 for each checkup required every 6 weeks, plus parking fees and gas etc., for 22 cycles! My mother participated in a trial at NIH and although they arranged her plane flights, they didn’t provide a place to stay, when she had to be near Bethesda, MD for about 3 days every month. Hotels in the area start at $200/night!

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Please understand : I am the patient who got Avastin, along with and after Frontline treatment,  which is not SOC. I am now in the SOLO2 trial. My mother participated in a trial of carboplatin & olaparib for treatment of recurrence,  including measurement of the pharmacokinetics of their interaction, in an attempt to determine which to administer first. My experiences with my own clinical trials have been positive aside from unexpected costs. However, my experiences with my mother’s clinical trial were vastly different and often quite negative.  Part of the problem seemed to be that nobody cared for her as a person, but rather as patient # whatever. But please don’t tell patients that clinical trials will be “at no additional cost”; it’s just not true. 

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@camdamiller

With 2 sisters with Ovarian cancer and a third one with Breast, will I be eligible to do the gene testing and be covered by insurance?

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What about the PPAACA provision saying that genetic counseling & testing must be covered for high-risk women? 

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