Question about ultrasensitive PSA: Significance of low number?

Merry Christmas. I just received results with PSA at <0.1 (at VA and not ultra sensitive). I'm declaring "UNDETECTABLE ". My PSA in Mar 2022 Was 80+. The diagnosis was aggressive high risk PCa with pelvic LNs. Treated with IMRT, Lupron, 4 months of Zytiga (19 mos to go) . I'm stunned by the decrease.
The next test is at Mayo and I'm requesting U.SENS.. I don't expect a number like yours for a while. Congratulations
The struggle now is to keep it down. The IMRT is still in KILLING mode for 1.5 to 2 years after radiation ends. That teamed up w Zytiga, and Lupron is the AMMO. I expect to be highly nervous at test time in 2024 and forward. Outside of test time I'll be thanking God and hugging grandkids.
Best of luck to you and yours. Keep us posted w your progress.

This value probably represents the analytical detection limit of the particular PSA test method employed. If this is the result of a PSA test on you, it represents good news, suggesting successful treatment or suppression of disease. It would be of interest to share a little more: PSA at time of diagnosis, how long ago, and any timelines for treatments initiated and associated PSA values along the way. We are all on the same journey. We just begin it at different starting points of our awareness. Good luck on yours.

It means your treatment is working, so great news.

You and your medical team will have decision to make and you may want to be thinking about them.

It will help the group if you describe the treatment plan:
How long did your medical team say you would be on the Lupron and Zytiga?
Frequency of monitoring - PSA tests, imagining and with what?
Was there any discussion about a specific period of treatment and if the results were what you are experiencing, stopping treatment and actively monitoring?

Some men do go off treatment based on certain criteria, others stay on it indefinitely. They key for the former is to have criteria for doing so and a plan for active monitoring after you do with criteria and decision points for resuming treatment. The challenged associated with the latter are of course the side affects, becoming castrate resistant at some point though when can vary immensely.

So, congratulations, you have won the opening round, now, what's your plan for the next part? It may help to think of managing your PCA in 3-5 year periods...will this work for the next 3-5 years and then what will be the next choice given the rapidly expanding (dizzying may be a better word) treatment options that come into clinical practice.

Kevin

I asked how long, my surgeon initially said 2 years on Lupron. I check my Psa every 3 months. But their tests only showed undetectable to less than .1 .Heck at .2 we would be getting a PET scan. So I got an ultra sensitive test. First time. I think from this point, that’s what I want.
I’ve been on Lupron for a year. I’m in the mindset of being proactive, so my oncologist worked with mayo, and I started zytiga 3 months ago.
From this point my oncologist said the length was an arbitrary number. No one has the answer. So I call my own shots. This is my rabbit hole. I’m researching less evasive options. Call me crazy but Ivermectin has been found to kill Pc in test tubes and mice.
My next visit I’m asking for a prescription. It looks like .2 mg dose a few months apart. It can’t hurt.
I understand the risks of continuing or discontinuing my meds . I think at one year I’m stopping zytiga. Lupron at 3. But my side effects from Lupron are almost nonexistent, so I’m mot sure if I’ll wait till I’m castrate resistant.
No one has a plan.
Thanks for your feedback.
God is good

I was a Psa of 97 in march of 21
3 after RP in Dec. 1.1 in Jan22 after starting Lupron .
and undetectable >.1 after 40 rounds of IMRT.

What information have you seen on ivermectin?

Ihave the same question....I know Ivermectin was in use during Covid infections but what is it's effectiveness with prostate cancer?

Has anyone with prostate cancer taken Ivermectin, and if so, how much did you take and how did it go?

I’m not promoting ivermectin just stating my results. I’m post Rp Jan2022, 7 months relugolix( orgovyx), in lieu of lupron n zytiga, 7 weeks of imrt for prostate bed n three Ln’s lighting up. Psa dropped to .37 from 12 after all the trx. Got off adt, testosterone returned to 585 and so did the psa to 6. Did psmA scan, two ln’s not visual n third one half the size it was, got back on adt and psa dropped to .76. After extensively reading n researching the article on ivermectin being repurposed as possible anti cancer ♋️ drug, decided to try it. Took 48mg every other day, six doses for 12 days. Got off adt after third dose n tested, liver readings were good ( down) test