Has anyone had experience with systemic fungal infection in a child with a normally functioning immune system? My daughter has a host of problems, including chronic sphenoid sinus disease with recurring polyp.
She just had her second sinus surgery. In the month prior to the surgery she had a urinary tract infection with positive urine cultures for Klebsiella pnuemoniae. Her only symptoms were feeling achy and having right flank pain. They put her on Macrobid. That didn't resolve her symptoms of right flank pain and she still felt achy, so they put her on a round of Septra.
She saw an ENT at that point because she has chronic sinusitis and thick nasal mucus with cough. A CT showed showed significant ethmoid sinus infection and a sphenoid nasal polyp--the same symptoms she had prior to her first surgery a few years ago.
Because of a similar history with her brother and because he presented with the unusal symptom of oral thrush a year before, a doctor told me to be sure that if she be checked for fungal infection. I asked the ENT to culture for fungus when he submitted her tissue for culture following this recent surgery.
Her cultures were negative for bacteria, but positive for Candida albicans, a fungus/yeast.
From what I have read and from what a general practitioner advises, she could have a systemic fungal infection. He put her on Diflucan four days ago. Now she is having the symptoms of "die off." Fever, sweating, feeling flu-like.
I'm cautiously optimistic that we may have figured out what has eluded us for years as an explanation of her various symptoms.
Has anyone here experienced a systemic fungal infection that was effectively treated? She is not immunocompromised. She does have multiple antibodies of type 1 diabetes and has autoantibodies for thyroid peroxidase and thyroglobulin. But from what two rheumatologists have told us, her immune system is working perfectly fine.
She has thyroiditis shown on PET scan. Is it possible her body is attacking various tissues because of fungal infection? If this is a systemic problem, can anyone recommend a doctor to see? The ENT is referring us to an infectious disease specialist locally, but if anyone knows of someone particularly qualified to handle this condition, I would love to have those recommendations.
Thanks for any input.