Has anyone switched from Eligard to Orgovyx? Help with joint pain?

I made a similar switch from Firmagon (injectable) to Orgovyx (pills) in spring 2024. There was a huge improvement in my quality of life. I still experience the chronic side-effects of testosterone deprivation, which I mitigate with diet, physio, exercise, and a desk fan 🙂 — but it's wonderful no longer having dealing with the acute symptoms that came after each monthly injection: I had 2-3 days of flu-like symptoms, aching legs, and swelling as big as an egg at the injection site.

If I wanted to sum it up, it was like getting off the roller coaster (a mega-dose every month) and onto a smooth, level train track (a micro-dose every day).

Good move. I was on Lupron for six years and switched to Orgovyx three years ago. Fewer hot flashes and no real issues with it. Some people say they get fewer side effects. Your testosterone comes back quicker When you stop, as long as you’ve been on it for a while.

I don’t know why they say it could help with joint and back pain. Never heard anybody say that.

Eligard also tends to leave. Plaque in the arteries. Orgovyx Doesn’t do that.

@jeffmarc As I've mentioned, in the U.S. Orgovyx is much more expensive than injectables, but here in Canada it's priced the same (about US $215/month), so there's no incentive for provincial governments or insurers to push patients away from it.

It's strange that so many Canadian oncologists still default to prescribing the injectables, with all the extra discomfort and inconvenience they bring. I can think of only 3 reasons:

1. Inertia (it's been available only since 2024, and oncologists at smaller centres might not be familiar with it).
2. Treating patients with dementia or other memory issues (who might not be able to take a daily pill reliably).
3. Treating patients who've had a reaction to Orgovyx and need to use a different type of ADT.

In my case, it wasn't even an opportunity to see my doctor every month: after I left hospital, they wanted to send me to an "infusion centre" every month for my Firmagon shot, but I pointed out that would be impractical with me in a wheelchair at the time, especially in winter, so Home Care kindly trained my spouse to do the injections. She kept it up for over two years (and deserves a caregiver medal for that, if there were such a thing, since it's a complicated shot that even the hospital nurses complained about).

Thank you for the replies!