Should I add Lipfendra to lower my LDL?
I am 81 years old, have CKD-5 with Stage 2 (GFR ~25) high blood pressure (150/70).
Even with an excellent diet, my Cholesterol LDL is elevated:
Cholesterol, Total 01 206 High 205 03/06/2026 mg/dL 100-199
Triglycerides 01 183 High 122 03/06/2026 mg/dL 0-149
HDL Cholesterol 01 61 59 03/06/2026 mg/dL >39
LDL Chol. (Direct) 01 102 High 113 03/06/2026 mg/dL 0-99
LDL (Dir.)/HDL Ratio 1.7 1.9 03/06/2026 ratio 0.0-3.6
I eat nearly no meat, lots of fruit and veggies, a Renal Dietition approved diet via Nourish and I exercise every day.
Would adding a Cholesterol lowering medication reduce my blood pressure and slow the rate of decline in my kidney loss?
Interested in more discussions like this? Go to the Chronic Kidney Disease (CKD) Support Group.
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Just be careful of any new med—some are hard on the kidneys.
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1 Reactionhow would I know? I read several of the research papers, but no one seems to have the answer.
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1 Reaction@stuartbell This is a very recently approved FDA drug to help lower cholesterol. As you know, we are not medical doctors here on Mayo Clinic Connect. It is beyond our scope and a violation of community guidelines to offer medical advice, which is what you are asking us to do.
I strongly feel this is something you need to speak about with your medical team. They know your personal situation far better than anyone here does. When will you speak to them, next?
Ginger
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2 ReactionsI am not asking for medical advice.
Two nephrologist at Mayo Clinic declined to accept me as a patient so that really is out of the question.
What I’m looking for is experience that others may have had with a drug.
I understand your position, but I was hoping to find another person like me who the nephrologist don’t wanna treat, but as managed to take this drug and had good results with it.
This is a frustrating disease. Other than general advice, the nephrologist I’ve seen are primarily recruiting for their dialysis laboratory.
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1 ReactionI control all of the above metrics with the help of my primary care physician and cardiologist. Talk to them as soon as possible. Meanwhile, ask this question of your favorite chatbot and you'll get an article and chances to ask follow up question in a matter of minutes. Use the info you get from the chatbot's survey of literature that most physicians cannot see unless they also use a chatbot for you. I'm 85 and have been on strict renal dialysis, exercise and sleeping routines for years. Still going strong and feeling very lucky to be alive and active.
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2 Reactionsthank you. I have done that bread Bette of the original articles, but I was looking for experience of people that have taken the drug.
I appreciate your reply and good luck in your battle.
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1 Reaction@stuartbell I never even heard of Lipfendra much less taken it or have experience with it but I’d like to respond anyway. Besides talking to your primary, a cardiologist or nephrologist you could talk to a pharmacist to ask what they know about Lipfendra. Could you do that?
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