Treated with CPAP, BIPAP (without oxy, with hermidifiers), and separate oxy only (now), 4 pulmonary doctors, nuclear echoes, etc. Main problem - got to bed relatively ok but beginning about 4 am experience extreme weakness(not really fatigue) so when get up am basket case for several hours, gradually improving during day. Seems that something occurs during night to cause this, possibly use of CPAP/BIPAP. To date no help from experimentation. Wondering if extreme loss of energy/weakness has been experience by others using CPAP/BIPAP. Any thoughts would be appreciated.