PPIs and Osteoporosis
Hi, I recently joined Mayo Clinic Connect and appreciate all the support that is shared here! I want to ask about PPIs and osteoporosis without writing a novel so I'll try to be brief.
2012 – Just before I turned 50, I was diagnosed with celiac disease (silent, no digestive symptoms) after extreme, unexplained weight loss. My endoscopy showed my small intestinal villi were cobblestoned. I lost 20% of my bone density, I had osteopenia in one measure and borderline osteoporosis in the other.
2015 – My bone density significantly improved on a gluten-free diet
2019 – Osteoporosis in both measurements, also discovered I was getting routinely glutened (again, no symptoms – I discovered this with a Nima gluten sensor) so I hoped removing this cross-contamination would allow me to reverse my bone loss again. I'm due for another DEXA scan shortly.
2021 – Had an endoscopy to check my villi which are fully recovered – hurray! However, I was diagnosed with duodenditis and esophagitis ( although I had no digestive symptoms).
My gastroenterologist prescribed omeprazole but that gave me abdominal pain so I stopped after two days. Then she recommended OTC Pepcid AC – which I took for 20 days but I started choking and throat clearing. Now she wants me to take lansoprazole for 90 days. I understand that PPIs interfere with calcium absorption and I don't want to lose more bone density but also want to heal my digestive system. I know bone fractures are associated with long-term PPI use but I already have osteoporosis so it seems like even short-term use is iffy. Has anyone here taken PPIs who had osteoporosis already? Did your bone density drop further? Also, do you know of any good references I could read about this?
Thanks for any information.