Patent Foramen Ovale, (PFO). My Granddaughter had a brain abscess a couple of months ago. Mayo found a PFO in her heart and closed it last week. I have suffered from migraine headaches since I was 5 years old. Would it be in my best interest to have tests done to see if I also have a PFO? I've read that PFOs may be the cause of migraines and some strokes and that they may be hereditary.