Pancreatic Cancer Daraxonrasib skin rash: What actually helps?

There actually is a fairly specific prevention and treatment approach now. The official RASONQUE guidance recommends topical corticosteroid treatment on the face/chest, fragrance-free moisturizing/emollient cream, strict sun protection with SPF 30+, and sometimes an oral antibiotic such as doxycycline or minocycline prescribed by the oncology team.

There are three approaches used by clinicians to proactively manage the rash that is associated with many using Rasonque (daraxonrasib). There is a corticosteroid cream, the antibiotic doxycycline and the Rx acne medication Accutane (generic 13-cis retenoic acid) that is effective in ameliorating the rash. The recommendation is in using these three compounds proactively before starting the regimen so there are therapeutic levels in the circulation before Rasonque is started.

@mcharlesfrancis how do you access the official Rasonque guidance?

@aparrish01 Here is a link to the resources page: https://rasonque.com/resources

@aparrish01 Ty.

For patients and caregivers, use the official RASONQUE patient website. Its Resources page has downloadable guides, including a Side Effect Management Guide, Rash Management Card, treatment journal, and discussion guide.

Ty

@tomrennie My husband might have to start this med. I am very concerned about its side effects 😕

My husband has been on it 53 days now and the skin rash is the only side effect he’s currently experiencing. The Pancreatic cancer had metastasized in June to his lymph nodes in his neck that were large and very tender to the touch. Since he’s been on the medication the lymph nodes have gone down, he went from taking oxycodone to extra strength Tylenol and now NOTHING! We’ll take THAT!!!!!

@casey1959 As you should be. From what I have learned, they can be challenging. But it sounds like others are finding ways to manage them the best that they can. Are there any that are of specific concern for you? Maybe others can share with is helping them manage them.