Has anyone has the Opdivo Yervoy combination protocol?

Posted by max326 @max326, Thu, Oct 31 5:19pm

Hello, has anyone been on this protocol? If so did it work for you and what were the side effects? I was DX in June with stage IV NSCLC. Treatment was standard of care, Carbo-Alitma-Keytruda. The lung responded, yet the liver mets progressed and increased, as did the brain mets. The Opdivo/Yervoy has been given to me as an option. Other options include chemo and clinical trails. Thank you for any feedback.

Max, I'd like to bring @maria146 @ginpene05 and @keeks into this discussion. They or someone they care about has experience with Opdivo (nivolumab) / Yervoy (ipilimumab) combination treatment and may be able to share experiences with you.

Are you leaning towards the Opdivo/Yervoy treatment or opting for a clinical trial?

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At this point I do not know which treatment plan I am going to go with. I have to hear the pros and cons of each. Any thoughts on clinical trials? Thanks

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Max – Go on Inspire.com and join for free. There is a whole thread on this combo that will give you the pros and cons.

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@seaspray

Max – Go on Inspire.com and join for free. There is a whole thread on this combo that will give you the pros and cons.

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@seaspray, did you have Opdivo/Yervoy? What was your experience?

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@max326

At this point I do not know which treatment plan I am going to go with. I have to hear the pros and cons of each. Any thoughts on clinical trials? Thanks

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@max326, You may be interested in reading this discussion on Connect, especially @burrkay's post about his wife experience on a clinical trial for stage IV NSCLC
– I took part in a clinical trial. Have you? https://connect.mayoclinic.org/discussion/join-a-study-at-the-nih/?pg=1#comment-303762

Which clinical trial was your oncologist suggesting?

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@colleenyoung

@seaspray, did you have Opdivo/Yervoy? What was your experience?

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Colleen – No, I have not had the combo of Opdivo/Yervoy. I was on Opdivo for over 3 1/2 years until I had progression and switched to another immunotherapy called Tecentriq. Here is the Inspire link. Max could at least hook up with the two others that just started the combo. https://www.inspire.com/m/Clementine9/journal/nivo-ipi-combination-treatment-stage-iv-nsclc/

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Thank you for your replies. I have look at the links both of you provided. Sure is a lot of information to process. The one clinical trial I have been submitted to is LungMap, waiting to hear if I qualify. We are going to MD Anderson on Wednesday. I am being treated at Northwestern in Chicago. The Opdivo/Yervoy can scare me a bit because of the possible side effects. When I have my options it will be decision time. Thank you again. And to anyone, I welcome any feedback on this combo or your experience with clinical trails.

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