jimg45, yes i know how to use high doses when need, it werid that high does cause me to gain weight, .I never been on prednisone before . I use cortisone my does are 15 am and 5 at 2 pm ,I can take to late oe cant sleep. This yr had trouble with pancreatics and was in for wk. They say when come in laspe test so high ,wonder why i was in coma, I was so sick, I have bradycardia too and chronis pain, headaches,polyglandular so deal with alot. thank you sharing.