Intermittent ADT

Posted by bonifasm @bonifasm, Oct 6 11:46am

Is anyone on intermittent ADT Therapy following external radiation and brachy therapy? I would like more information on this and or research for using intermittent ADT? Thanks

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My situation is not exactly what you asked about, but it’s close enough that I thought I would respond. I had RP 2 years ago at age 59. My PSA was 23, Gleason 4+4=8, stage 3 with seminal vesicle involvement. 60 days post RP, my PSA declined to 7. I started intermittent Bicalutamide in dosages between 50-150 milligrams per day. Got my PSA down to 0.23 in 6 months. Then stopped for 2-3 months until PSA rose above 2.0. Now I will be on the bicalutamide for 2-3 months then off for 2-3 months depending on how quickly the PSA rises and falls. I am being treated by a Dr in Mexico City. I go once a year for a PET/PSMA scan and I have two tumors in the prostate bed but no metastasis. My Mexican Dr says I can go on indefinitely like this, but I’m going to see an RO at Miami Cancer Institute in December who uses the MRIdian equipment to see if a cure is still possible. If the RO thinks there is a decent chance, I will go for it. I think the intermittent ADT is better for quality of life than constant ADT, but it’s still bad enough that if there is a reasonable chance of getting off it through RT, I will try it.

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@ddl

My situation is not exactly what you asked about, but it’s close enough that I thought I would respond. I had RP 2 years ago at age 59. My PSA was 23, Gleason 4+4=8, stage 3 with seminal vesicle involvement. 60 days post RP, my PSA declined to 7. I started intermittent Bicalutamide in dosages between 50-150 milligrams per day. Got my PSA down to 0.23 in 6 months. Then stopped for 2-3 months until PSA rose above 2.0. Now I will be on the bicalutamide for 2-3 months then off for 2-3 months depending on how quickly the PSA rises and falls. I am being treated by a Dr in Mexico City. I go once a year for a PET/PSMA scan and I have two tumors in the prostate bed but no metastasis. My Mexican Dr says I can go on indefinitely like this, but I’m going to see an RO at Miami Cancer Institute in December who uses the MRIdian equipment to see if a cure is still possible. If the RO thinks there is a decent chance, I will go for it. I think the intermittent ADT is better for quality of life than constant ADT, but it’s still bad enough that if there is a reasonable chance of getting off it through RT, I will try it.

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Thank you and good luck.

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Greetings;
My take would to have a short course of ADT first then have the radiation because the ADT weakens the cancer then the radiation finishes it off easily.
I don't totally agree with the doctor's opinion that you can go on ADT indefinitely because of the side effects.
Given that after RP the psa only dropped to 7 means that it is still out there and after the ADT it went from .23 to 2 in 2-3 months means that you have to get on it ASAP.
I researched the MRIdian and it is impressive.
Please keep us in the loop.
Best wishes

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Dr. Scholoz on Utube has many helpful videos on your situation. He would advise to get on Lupron since the cancer is in the bed of where the prostate was. I have a friend who got his removed 7 years ago and he had a similar Gleason 7 and PSA around 7 like me. He gets blood work done and if it bumps up from .1, he get a Lupron and he gets one about once a year. A 3 month one, I had no cancer per CT and Bone S. I had it removed 2.4 months ago. I go back on Nov. 16 for my first blood work. If the PSA is above 0, I get a PMSA Pet Scan and that identifies any spots. If a spot is detected where the prostate was, I get on Lupron. If a spot is outside of where the prostate was, I have the spot pinpointed and then targeted Beam Radiaition will poison the little bastard. I am 70 just now. I do the Kelgel and Pelvic exercises and now am working out hard again and doing Core exercises, 1,000 Crunches a day. I am on some pill for pee control but I swear to all of you, I pee 200 a day. I put up with it because I am so happy to be alive.

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