I used to be on Effexor for many years and decided to wean off. It was a horrible experience and am back on even though I had genotype blood test and the results came back that I have the gene cyp2c19 which doesn't metabolize Effexor. Effexor has helped me in the past but hasn't been helping me since June 15th 2011. I'm still very depressed and have an extremely difficult time getting out of bed in the morning. My doctor also added 300mg of lithium to boost the Effexor. There aren't many drugs that metabolize with this cyp2c19 receptor. Does anyone else have this problem? I hate feeling this way.