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KimG
@KimG

Posts: 2
Joined: Nov 04, 2015

I have been diagnosed with RA, primarily on symptoms alone. I only [...]

Posted by @KimG, Nov 3, 2015

I have been diagnosed with RA, primarily on symptoms alone. I only had mildly elevated CRP and a positive ASMA (but normal liver panel). I’ve discovered my symptoms are worse when I increase my sertraline, which is at a huge dose, and are better when I decrease it. I believe the SSRI might be giving me the arthritis. I also believe there might be a genetic reason the high doses of SSRI only help a little with depression – mainly because I have no CYP2D6 activity, which was recently discovered. But I suppose that is for another board! My docs have never heard of arthritis being caused by excessive SSRIs, but I’ve read some about it online. Does anyone have any more knowledge /experience with this?

REPLY

Hi @KimG
Welcome to Connect. Have you just recently been diagnosed with RA? How long have you been taking an SSRI?

I’ve been on Zoloft over 10 yrs. I was officially diagnosed with RA 2-3 yrs ago, but had the symptoms long before. They came on gradually (over years) and finally spoke to my GP who sent me to a rheumatologist.

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