I have been diagnosed with RA, primarily on symptoms alone. I only had mildly elevated CRP and a positive ASMA (but normal liver panel). I’ve discovered my symptoms are worse when I increase my sertraline, which is at a huge dose, and are better when I decrease it. I believe the SSRI might be giving me the arthritis. I also believe there might be a genetic reason the high doses of SSRI only help a little with depression – mainly because I have no CYP2D6 activity, which was recently discovered. But I suppose that is for another board! My docs have never heard of arthritis being caused by excessive SSRIs, but I’ve read some about it online. Does anyone have any more knowledge /experience with this?