Fast Tacrolimus Metabolism?
Hi all. Wondering if anyone out there was found to metabolize tacrolimus at a fast rate. The definition I've found is: (trough level / DAILY tac dosage) < 1.05.
I'll speak to the Transplant team tomorrow but curious about others' experiences. Did they swap out another drug for the tac? Wondering if anyone was changed to sirilimis. My concern is the nephrotoxicity at high tacrolimus doses.
Interested in more discussions like this? Go to the Transplants Support Group.
Hello. I am four months post liver transplant and take 8mg tacro in the am and 8 in the pm. Trough level is about 8. Is that typically reduced down the road? Thank you.
I’m 3 years post kidney transplant. My Tac level varied from test to test. I was put on Astagraf XL, which is only taken once a day in the A.M. That has helped stabilize my level.
Is anyone else taking Astagraf?
Yes, mine was high after transplant. It was often adjusted based on the latest labs. Expect that, mine was just adjusted as recent as 2 months ago. I trust that your journey forward will for the most part be smooth. As they say, life is a bowl of Cherries, but it has its pits! I trust you will have a pit free pie😊.
I hope your journey going forward will an angel leading you by the hand.
Happy New Year.
Thank you so much and prayers to you also. Happy New Year.
I want to add my thoughts from my experience as a transplant recipient to this discussion. Our medications start at a higher dose and over time they are reduced as our body adjusts to out new organ. I would like to say that each of us can be at a different dosage at any time. There is not a one-dose-fits-all. And there is not a standard measurement of timer for dosage to be changed. So much depends on pretransplant medical history, body size, body reaction, organ match, etc.
@patrickski98, Your doctors will look at your labs, all of them, as part of their decision for when/or if to make adjustments. Life as a transplant recipient is a journey, and your transplant team will provide the directions along the way.
Thank you very much for your response. I assumed that the dosage would eventually be reduced and I do realize that it will not be the same for everyone. Good luck to you in your ongoing journey.
For kidneys look into Glysine. Amazing
What benefits do you feel make this an amazing supplement?
Did your transplant approve for you to take this?
Improved all my kidney functions greatly. My tx team in NY recomended it . Now Im liver tx so you have to do your own research and consult your tx team!!!! All I can say is it worked for me,improved all my kidney functions by 30% . Do a google search — "Effect of Glycine on Kidney and liver function" Its a natural amino acid in our bodies and has been completly safe for me with no side effects for me . DO YOUR OWN RESEARCH , CHECK WITH YOUR TRANSPLANT TEAM IF ITS OK FOR YOU , WHAT WAS GOOD FOR ME MAY NOT BE GOOD FOR YOU!! '