Evenity and triglycerides

hi, mbk4690.
raised triglycerides are not noted in the clinical trials. Someone else did have the same effect from Evenity https://connect.mayoclinic.org/discussion/evenity-and-chloresterol/
Folic acid dropped my triglycerides by a third. I took 800mcg for a month between the two tests.

@gently I've had an increase in the following and assumed it was due to age (lack of estrogen). I wonder if Reclast could be involved...?
Cholesterol
Normal value: < =200 mg/dL
224High

LDL Calculated- Hopkins-Martin
Normal range: below < =130 mg/dL
131High

tillymack,
Reclast, and other nitrogen containing bisphosphonates, are have been seen to raise HDL and lower LDL, improving the ratio, operating in the same pathways as statins. The effect is said to increase over time. It is also thought that Reclast protects our cardiac valves from accumulating plaque.
Your changes may be diurnal.
There is an unfortunate connection between osteoporosis and hypercholesterolemia.

Thanks so much!

So Reclast is helpful rather than harmful?

When you refer to diurnal, does that mean my results might change depending on the time of day my blood is drawn for the test?

Can you tell me more about the connection between osteoporosis and hypercholesterolemia?

Many thanks!

tillymack, researchers in one study suggested that bisphosphonates given for bone health may eliminate the need for statins in a person with both osteoporosis and hypercholesterolemia. The literature is mostly associative not causative and identifies common causation.
Cytokines like osteoprotegerin (OPG) reduce the formation of osteoclasts in the bone and when released by the vascular muscle reduce inflammation and atherosclerosis. Both through a pathway called RANKL. Estrogen increases the production of OPG.
I once thought that calcium intake was distributed in the vascular muscle instead of on the bones in a more direct subversion of the more healthful path.
https://josr-online.biomedcentral.com/articles/10.1186/s13018-022-03485-8 pretty much just statistics.
This 2020 article gets a little closer to saying that lipid disorders might be causative.
"[Lipid metabolism] is closely related to bone metabolism, and lipid metabolism disorders can directly affect bone formation and resorption, thereby affecting BMD and strength." https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.578194/full This one is much more interesting though a little harder to wade through.
The cardiologist I saw was unaware of any connection and not familiar with the osteoporosis medications.
If I find out anything, I'll post to you and hope you'll do the same for me.