I switched from citalopram to Effexor 6 weeks ago and it's been a rough transition. Did 37.5 mg for about 10 days while gradually coming off the citalopram. Then 75 mg for a few weeks then have increased to 150 mg about 5 days ago. So, I feel so strange!!! I've been up and down with my moods. Can be good 2 to 3 days then really bad for 2 to 3 days. Past 3 days so fatigued, just the feeling like I need to LAY DOWN! Lots of sighing too. Hasn't it been long enough for the Effexor to kick in? I started counseling prior to making the switch too.